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Mutation, Randomness, and Evolution scientific from the importance of knowingWhat does it mean to say that mutation is random? How does mutation influence evolution? Are mutations merely the raw material for selection to shape adaptations? The author draws on a detailed knowledge of mutational mechanisms to argue that the randomness doctrine is best understood, not as a fact based conclusion, but as the premise of a neo Darwinian research program focused on selection. The successes of this research program created a blind spot