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Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment
To view a copy of this licence, visit About this article Cite this article Shi, Y., Wei, Z., Feng, Y
Along these lines, an emerging theory linking excitotoxicity and mitochondrial dysfunction suggests that an accumulation of lactate, a metabolic byproduct which is toxic (especially to nerve cells) at high concentrations may play a role in ALS progression (Vadakkadath Meethal 2012)
The roles of complexes III and IV in apoptosis are less clear, but the electron carrier between the two complexes, cyt c , has been known as a key player by activating apoptosis protease activating factor-1 (Apaf-1) when released to the cytosol
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