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A total 10 4 cells were included in the analysis for each experiment

10.3389/fphar.2023.1146960 26 HlscherC

Cells were collected at 0 h and after 24 h incubation at 37C or 26C, mixed with 0.4% trypan blue solution, and counted using a hemocytometer

Known inhibitors of TGRs/TrxRs, which include metal complexes and compounds containing Michael acceptors or oxadiazole oxides 19,23,24 , usually react with Sec and Cys residues and other biogenic nucleophiles irreversibly

6g), mitochondrial adaptations following dual SHP2/MEK inhibition appear to correlate with oxidative stress and lipid peroxidation within tumor cells

Mitochondria in the control group consistently showed a decrease in size and an increase in membrane density according to TEM imaging