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In contrast to breast cancer, p28 induced a significant, time-dependent increase in TAp63 in p53 wt and p53 null melanoma cells (Figure 8), but a decrease in p53 mut Mel-23 cells

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YM performed in vitro experiments

Lachowiez C, DiNardo CD, Takahashi K, Loghavi S, L-C X, Kadia TM, Daver N, Adeoti M, Short NJ, Sasaki K, Wang SA, Borthakur G, Issa GC, Maiti A, Alvarado Y, Pemmaraju N, Montalban-Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M , Garcia-Manero G, Kornblau SM, Ravandi F, Jabbour EJ, Konopleva M, MD, and Kantarjian H

Choline (especially CDP-Choline)