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Side Effects: Sedation Parkinsonism symptoms QT prolongation (may be significant if taking with drugs inhibiting CYP3A4/5 or 2D6) Pharmacokinetics: undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 deuterated active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug twice a day dosing effect half life 9.4 hours (Schneider et al, 2021) HT: Resistant Hypertension

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Who your information may be shared with Responses to the consultation may be seen by: DHSC officials such as policy, data analysts, economists and others working on tobacco and vapes policy officials from other government departments including the devolved administrations of Scotland, Wales and Northern Ireland, where appropriate DHSCs third-party contracted supplier SocialOptic, which is responsible for hosting the online consultation We may also share anonymised data with other government departments