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Interestingly, Nrf2 phosphorylation in this domain may affect Keap1 binding and thus stabilise Nrf2 impeding proteasomal degradation

Taking into account the situation of these patients who had no complete response to treatment, their partial response was notably better in patients supplemented with melatonin [67-69]

Furthermore, alogliptin prevented the phosphorylation and degradation of IB, nuclear translocation of NF-B p65 and suppressed IB/NF-B signaling [35]

While the DEX group showed no change in (MDA & NO), animals given SPAE (400 & 800 mg/kg) showed a considerable improvement in (CAT & SOD)

Specifically, this first part considers the application of digital technologies at the service of smart cities and territories