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[Updated 2024 Jan 31]

Overexpression of the leptin gene in adipocytes and increased circulating levels of leptin may also contribute to enhanced basal lipolysis in obesity (74)

All quantitative efficacy data (body-weight loss, fat-mass reduction) comes from a single diet-induced-obese mouse study

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B 12 status compared with pregnant women of European ethnicity

Failure to do so will result in return of the anemia and in development of incapacitating and irreversible damage to the nerves of the spinal cord

Phase 1: Establish tirzepatide baseline (weeks 1-4) Start tirzepatide alone at 2.5mg weekly