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Puerarin ameliorates colitis by direct suppression of macrophage M1 polarization in DSS mice

Epitalon: A pineal-derived peptide shown to regulate melatonin and telomerase activity, supporting circadian rhythm and cellular longevity

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Expected timeline: Weeks 1-2: Minimal observable changes, body adjusting Weeks 3-4: Possible reduction in baseline inflammation Weeks 5-8: Gradual improvement in energy, reduction in minor symptoms This protocol focuses on two well-studied peptides with complementary mechanisms

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doi: 10.1016/j.cell.2013.12.010 48 ZouYPalteMJDeikAALiHEatonJKWangWet al