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Studies on HUA-induced cardiac remodeling have determined that sUA prompts cardiomyocytes to manufacture CXCL1 and CXCR2, which induce macrophage migration

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Annals of the New York Academy of Sciences, 1194 , 118124

In particular, transforming growth factor- (TGF-) is regarded as one of the main mediators of the deleterious effects of the diabetic milieu, and is known to mediate kidney fibrosis and tubular cell death under diabetic conditions 11,12,13

[8] Poor vision caused by cataracts may also result in an increased risk of falling and depression