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The loliolide enhanced the size of human DPC spheroids and increased the expression levels of IGF, KGF, and VEGF

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doi: 10.3390/ijms21176413 44

However, with continued exposure, immune activation may fail to resolve appropriately

Dosages used in the reviewed studies ranged from 600 to 3600 mg per day for 8 weeks to 1 year, with studies using dosages of 10002000 mg per day showing the best responses

NRF2 is a major target of ARF in p53-independent tumor suppression