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Furthermore, the intervals between an inflammatory stimulus, the massive generation and complete activation of lytic enzymes, and the accumulation of glycocalyx degradation products, which causes changes in microvascular permeability that can be relatively prolonged (102)

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Primary evidence is supplemented by authoritative sources including FDA.gov, NIH.gov, MayoClinic.org, and ClevelandClinic.org due to limited recent peer-reviewed publications on FDA status and long-term safety for this specific query

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