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Supportive care

Oral NSAIDs, such as ibuprofen, naproxen, and celecoxib, have demonstrated consistent efficacy in reducing pain intensity and improving joint function across numerous randomized controlled trials and meta-analyses (Pelletier et al., 2016

10.1002/rmb2.12006 Reprod

For a general deficiency, many protocols start with 100 mcg injections daily or every other day for the first week

However, due to lower affinity for IGF-I, IGFBP-1 is usually in an unsaturated state and changing plasma concentrations of IGFBP-1 becomes important in determining the unbound fraction of IGF-I