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We observed strong induction of proliferation for all of the above cells in the presence of aMD5-PEG11, with proliferation levels nearly the same as those induced by the control hHGF

BMJ 341 , c4372 (2010)

Document indication and rationale (especially when FDA alternatives exist)

Understanding these signs can help researchers and clinicians identify when BDNF support might be beneficial

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To further mitigate risk, many studies involve sentinel subjects typically only 1 participant on the active drug and 1 on placebo who receives the investigational drug before the remaining participants in the cohort are dosed