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Copper ions delivered by GHK-Cu also demonstrate up to 90% inhibition of type 1 5-alpha reductase at specific concentrations

At 5 mg/mL, a 2.5 mg dose is 50 units instead of 25

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This review integrates current evidence on how brain peptides contribute to AD pathophysiology, summarizes recent progress in peptide-based therapeutic strategies and delivery platforms, and critically examines the remaining barriers to clinical translation, including bloodbrain barrier penetration, metabolic stability, off-target effects, and the need for biomarker-guided patient stratification