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ACCLAIM: a randomized trial of abatacept (CTLA4-Ig) for relapsing-remitting multiple sclerosis

Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)

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This critical balance between survival and cell death is orchestrated by the coordinated activity of the three canonical UPR branches, IRE1, PERK, and ATF6, which together determine cell fate decisions under stress

Both cell types can also respond to TGF- through TGF- receptor