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They cannot by themselves establish: A safe human amount A safe route of administration Long-term human safety Interaction risks Reproductive or developmental safety Clinical effectiveness Which individuals, if any, might be suitable for an authorised use The number of animal papers should not be presented as equivalent to a programme of large, well-controlled human clinical trials

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Rushworth and Megson, 2014

Genetic rearrangements among the RET tyrosine kinase domain and heterologous genes are the root of RETs carcinogenic potential in PTC