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HCV-induced ROS play a significant role in HCV pathogenesis, as Kupffer cell activation contributes to pro-fibrotic cytokine and ROS production, leading to hepatic damage 91,92

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Notably, NKT cells constitute 20%30% of lymphocytes in mouse livers, but account for less than 5% in human livers ( 3 Crosstalk between gut microbiota and immunity in NAFLD GM participates in the onset and progression of NAFLD through the Gut-Liver Axis (Wu et al., 2021)

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