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Early warning signs include persistent fatigue that does not improve with rest, difficulty concentrating or brain fog, tingling or numbness in hands and feet, weakness in the legs, dizziness when standing up, pale or yellowish skin, and a sore or swollen tongue

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Moreover, nonneutralizing binding antibodies to S2 have been linked to vaccine-mediated protection in a murine model using an alphavirus vectored pan-sarbecovirus [72]

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