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5 Synergistic therapy and clinical translation The significant interindividual variability in SFN response is not a barrier but an opportunity for precision medicine

Nieman DC, Mitmesser SH

Khi thiu Glutathione , c th s gp phi nhiu vn sc khe nghim trng do mt i kh nng chng li cc gc t do v c t

doi: 10.1172/JCI180076 154 CaielliSVeigaDTBalasubramanianPAthaleSDomicBMuratEet al

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(2018) identify the activity of the first committed enzyme of glutathione synthesis, Glutamate Cys ligase (GCL/-ECS/CAD2), as a key determinant of S flux into not only glutathione but also protein synthesis