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One option is a prolonged course of vancomycin therapy with a subsequent gradual tapering (eg, 125 mg 4 times daily for 2 weeks, 125 mg twice daily for 1 week, 125 mg daily for 1 week, 125 mg every other day for 1 week, and 125 mg every 3 days for 2 weeks)

This allows the reconstituted solution to remain stable for approximately 30 days when refrigerated

DSRIP Background B1

5c and Extended Data Fig

And in Novo Nordisks CagriSema trial, 40% of participants did lose at least 25% of their body weight just not enough to bump the trials overall average result past that benchmark

Concentrations above start to see increased transepidermal water loss (TEWL) and reduced hydration