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In that document, ICH representatives recognized important pharmacokinetic differences between younger and older patients related to renal and hepatic function, as well as drug-drug interactions

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YangYWengWPengJHongLYangLToiyamaYet al Fusobacterium nucleatum increases proliferation of colorectal cancer cells and tumor development in mice by activating toll-like receptor 4 signaling to nuclear factor-B, and Up-regulating expression of MicroRNA-21