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While generally less bothersome than nausea or vomiting, constipation can persist longer and may require proactive management through increased fiber intake, hydration, and physical activity

By enhancing autophagy, spermidine may support longevity, reduce inflammation, and contribute to healthier ageing across tissues

Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy

It is used to assist with the management of neuropathies

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Patients frequently report more profound, more restorative sleep as a welcome side effect of treatment