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Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain

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Treatment is also burdened by poor medication adherence, high patient discontinuation, or qualitative HbF level assessments every 36 months (Agrawal et al., 2019)

Shah et al

When endothelial cells release nitric oxide, nearby smooth muscle cells in the blood vessel wall respond by relaxing