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Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells

[DOI] [PubMed] [Google Scholar] 25.Liu J, Takase I, Hakucho A, Okamura N, Fujimiya T

The results of pharmacokinetic analyses performed in normal volunteers show that following 4 mg SC, a peak plasma level 3 ng/mL (2.4 nmol/L) was obtained with a terminal half-life of 20 min (21)

Most of cancers progress from the chronic diseases or symptoms, and in this context, initially prescribed drugs against the chronic disease such as statin and metformin might be continually administrated during cancer treatment

In MAFLD, hepatic lipid accumulation induces excessive ROS production, which in turn promotes lipid peroxidation, accelerates lipid accumulation, and induces cellular damage

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