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Both nutrients exert antidepressant effects through gut microbiota regulation, either by enhancing SCFA production or reducing inflammation, making them the most promising candidates for clinical translation (consistent with Sections 4.3, 5.3)

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The combination limited and variable BBB transport plus rapid plasma degradation means peripherally administered DSIP delivers a brief and structurally heterogeneous exposure to the central nervous system, complicating dose-response interpretation in any whole-animal experiment