Bulletin of Experimental Biology and Medicine , 137(4), 389391
Because these toxins negatively affect kidney function, they are implicated in kidney damage in CKD (Montemurno 2014
Studies using animal models and in vitro systems to explore the impact of sustained O-GlcNAcylation modulation will be critical to identifying and mitigating risks, ultimately leading to safer, more effective CNS-targeted therapies
Recent studies show that FSP1, when recruited to the plasma membrane, functions as an oxidoreductase reducing ubiquinone (coenzyme Q10, CoQ 10 ) to ubiquinol (CoQ 10 H 2 ), which acts as a lipophilic radical-trapping antioxidant to inhibit ferroptosis, and therefore it was renamed as ferroptosis suppressor protein 1 (FSP1) 32,33
Spine (Phila Pa 1976)
10.1016/S0306-4522(02)00292-0 10 ArvidssonO.GillbergC.LichtensteinP.LundstromS