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G6PD deficiency Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency

While tirzepatide preserves lean mass better than diet alone, some researchers look for ways to further protect muscle during aggressive weight loss

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The study population had an estimated baseline coronary heart disease risk of 11.6% over 10 years based on the Framingham risk criteria and included a high percentage of patients with additional risk factors such as hypertension (58%), low HDL-C levels (23%), cigarette smoking (16%), or a family history of premature CHD (12%)

It was historically common but has been largely replaced by thinner options

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