At first glance, glutathione is similar to other well-known antioxidants such as vitamin C and vitamin E
10.1016/j.biochi.2015.04.014 Biochimie
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Thus, not only the size but also the charge and shape of the glutathionylated substrate are relevant with GS in GSSG being the optimal leaving group in accordance with a 2nd glutathione-interaction site (Fig