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K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts

WHO defines anemia at Hgb below 13 g/dL for adult males and below 12 g/dL for adult females

Many patients with diagnosed deficiency find their symptoms significantly improve after targeted supplementation, with over 90% reporting positive changes within a few months of treatment

Caballero MR, Lukawska J, Lee TH, Dugu P