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2-3% ( Low nicotine vapes ) : Light and casual

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Evidence suggests multiple interrelated pathways of liver injury: Nicotine-induced injury : Nicotine is metabolized in the liver via CYP2A6, where it activates 7-nicotinic acetylcholine receptors (7-nAChR), leading to oxidative stress, mitochondrial dysfunction, and pro-fibrotic signaling [36, 125, 126]

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Researchers have also focused on vitamin E acetate, a thickening agent that is added to some THC vaping liquids