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The rabbit pyrogen test and the Limulus amebocyte lysate test are both specified in the United States Pharmacopeia Chapters and (USP23/NF 18, Biological Tests, The United States Pharmacopeial Convention, Rockville, Md., 1995)

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An elevation in the level of mitochondrial oxidative stress and the opening of the mitochondrial permeability transition pore (mPTP) was also observed