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This existing toxicological data could streamline the regulatory approval process for a repurposed oncological indication

Summary High homocysteine concentration in the blood is associated with an increased risk of cardiovascular disease (CVD)

The disulfide bond between Pt GSTF8 residue C13 and GSH was reduced on-column with 20 column volumes of rPPS buffer (20 mM potassium phosphate, 200 mM NaCl, 10 mM DTT, pH 7.4), at a flow rate of 5 ml min 1 and the column was then washed with 40 column volumes of PPS buffer at a flow rate of 5 ml min 1 to remove free GSH

Streptozotocin is a naturally occurring agent toxic to pancreatic beta cells (Seven et al

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However, given FABP5s broad metabolic roles, tissue-restricted or transient inhibition will likely be needed to avoid systemic lipid perturbation