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The increase in aberrant APP proliferation eventually leads to the amyloid beta (A) plaques that have been previously associated with AD (59), emphasizing the role of neuroinflammation in the development of continuing injury long after TBI occurs

Changes in actin polymerization status can affect focal adhesion signaling complexes, integrin-mediated signaling, and transcriptional responses that govern cellular movement and structural adaptation

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Therapeutic intervention protocols for opioid addiction are available but are at higher doses and for longer duration of intravenous administration, at times lasting over 18 hours