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Subcutaneous injections are administered under the skin into fat between the skin and muscle

Fatigue was reported by three Caucasian subjects, of whom one subject received apixaban and two subjects received placebo

Pregnancy / breastfeeding: no safety data

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Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs

Anaphylactoid reactions are uncommon (especially if the initial dose is infused more slowly, over 60 minutes)