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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

We observe a resolved section of the R-domain that is most highly conserved in the ABCC family and includes the phosphorylation sites (Fig

Conversely, drug clearance may be a useful indicator of the functional consequences of heart, kidney, or liver failure, often with greater precision than clinical findings or other laboratory tests

The mechanisms are different enough that interactions are unpredictable

Neuropharmacology 136 , 182191 (2017)

Oral Minoxidil is FDA-approved for hypertension but is prescribed off-label for hair concerns at lower doses