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OTUD5 counteracts UBR5-mediated K48 ubiquitylation, overcome by TRIP12 To investigate whether OTUD5 counteracted ubiquitin chain assembly, we conducted an in vitro ubiquitylation/deubiquitylation assay using wild-type or catalytically inactive (C224R) OTUD5 (OTUD5C224R)

c , Relative fold change in Huh7 cell growth treated with vehicle or R162

16 (Suppl 1), 710 (1989)

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Review Article OPEN ACCESS Author information Abstract Cancer is a hereditary multifactorial disease, and due to its rising incidence in both young people and adults along with its substantial burden, oncological emphasis has been placed more on preventive efforts

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