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The convergence of all of these proteins on mitochondrial dynamics uncovers a common function in the mitochondrial stress response that might provide a potential physiological basis for the pathology of PD (Norris et al., 2015

2024;28 doi: 10.1111/jcmm.70188

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Additionally, shRNA sequences targeting CHAC1 90 or CHAC2 were cloned into a modified version of the doxycycline inducible LT3GEPIR vector 50 , where the puromycin resistance cassette was replaced with a zeocin resistance gene to generate cell lines with temporal control of CHAC1 depletion

Theyre also ideal for vegetarians and vegans, since B12 is primarily found in animal-based foods