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inside-out (arguing that a primary CNS degeneration triggers secondary autoimmune inflammation in an immune-predisposed patient) hypothesis (Sen et al., 2020

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The dosage protocol matters because TB-500s mechanism relies on sustained tissue signaling rather than a single acute dose

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Preclinical research Much of the published literature involves cells and animal models rather than controlled human studies

doi: 10.1038/oby.2008.412 31