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Immediate medical attention is warranted if missed periods are accompanied by concerning symptoms such as severe abdominal pain, heavy bleeding, abnormal vaginal discharge, signs of pregnancy, symptoms of thyroid dysfunction (significant fatigue, cold intolerance, hair loss), or signs of hyperprolactinaemia (galactorrhoea, visual disturbances, headaches)

Pyridoxine is categorized as pregnancy category A, meaning controlled studies have shown no risk to the fetus

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Most research protocols don't require accounting for overfill at the individual-dose level