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The most common suspected adverse event reported was subacute thyroiditis, followed by Graves disease with other incidental reports of painful thyroiditis, silent thyroiditis, concurrent Graves disease and subacute thyroiditis, thyroid eye disease, overt hypothyroidism, atypical subacute thyroiditis, and painless thyroiditis with thyrotoxic periodic paralysis (133)

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In biochemical enzymatic assay in vitro, NE and DA dose-dependently inhibited the reductive activity of PDI