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In fact, it is not only tumor microenvironments which can educate immune cells since for instance, the GM-CSF can license murine and human monocytes toward their immunosuppressive phenotypes through the PI3K/AKT/mTOR signaling pathway [90]

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There were very few mild side effects reported by the participants taking NAC in this study

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[206] reported the toxic effects of di- and tri-nitro toluenes and amino-nitrotoluenes and proposed that the liver toxicity could be a secondary effect of primary hematological toxicities caused by these compounds