The reduction in circulating estrogen can affect the activation of estrogen receptors, potentially leading to low-estrogen diseases such as metabolic syndrome, cardiovascular diseases, and obesity
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No evidence of significant endocrine disruption, hepatic, or cardiovascular adverse effects has been observed in available data when used within researched dose ranges
Steullet P, Cabungcal JH, Monin A, Dwi D, ODonnell P, et al
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Other areas for heightened scrutiny involve payment processor transaction flags for high risk medical or wellness services such as peptide therapy