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For the vascular side, GHK-Cu promotes angiogenesis through VEGF and bFGF expression, improves blood vessel integrity, and supports microcirculation

HTyr and oleuropein aglycone (OLE) inhibit Tau fibrillization, thereby reducing neurofibrillary tangle (NFT) formation and associated neuronal and glial pathology (39)

DISSECTION O - ESOC25-604 FIBROMUSCULAR DYSPLASIA AND SPONTANEOUS CERVICAL ARTERY DISSECTION: A SECONDARY ANALYSIS OF THE STOP-CAD STUDY Ahmad Nehme 1 , Liqi Shu 2 , Marion Boulanger 1 , Daniel Mandel 2 , Christopher Leon Guerrero 3 , Esther Kim 3 , Nils Henninger 4 , Bastien Rioux 5 , Aaron Rothstein 6 , Michele Romoli 7 , Setareh Salehi Omran 8 , Marialuisa Zedde 9 , Richa Sharma 10 , Shadi Yaghi 2 , Emmanuel Touz 1 1 Department of Neurology, CHU de Caen-Normandie, Caen, France, 2 Department of Neurology, The Warren Alpert Medical School of Brown University, Brown Medical School, Providence, United States, 3 Sanger Heart and Vascular Institute, Atrium Health, Charlotte, United States, 4 Department of Neurology, University of Massachusetts Chan Medical School, Worcester, United States, 5 Department of Neurosciences, Universit de Montral, Montreal, Canada, 6 Department of Neurology, University of Pennsylvania, Philadelphia, United States, 7 Department of Neurosciences, Bufalini Hospital, Cesena, Italy, 8 Department of Neurology, University of Colorado, Aurora, United States, 9 Neurology Unit, Stroke Unit, Azienda Unit Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy, 10 Department of Neurology, Yale New Haven Hospital, New Haven, United States Background and Aims: Fibromuscular dysplasia (FMD) is found in 6-14% of patients with spontaneous cervical artery dissection (sCeAD)

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We demonstrate that 1,6-HD effectively inhibits PSR-1 condensation in vivo and reduces axonal fusion triggered by overexpression of PSR-1