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injections varied depending on the test animal, reaching levels of approximately 1419% and 4551% in rats and beagle dogs, respectively

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Finally, from a general point of view, the consistent effect of NSAIDs (24, 25), and thereby, the consistent NSAIDs effects on sphincters failure in rat, and vice versa, the consistent sphincter failure related to NSAIDs, thus, a commonality for both NSAIDs and sphincter failure, could be hardly combined with the quite inconsistent effects of NSAIDs on sphincter pressure in different species so far reported (17-23)

While human cognitive studies are still needed, the preliminary data is encouraging