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The answer depends on what you value as a smoker

In senescent mice, chronic cotinine treatment reversed impairments in spatial and recognition learning and memories in the Morris water maze and novel object recognition tasks in a 7 nAChR-dependent manner ( Cotinine also improved cognitive performance in Fmr1 / mice, a murine model of Fragile X syndrome

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For instance, certain SNPs related to smoking initiation may modulate the rate of nicotine metabolism, affecting an individuals level of tobacco exposure and consequently increasing the toxic burden on the liver