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5.1 Intervention strategies 5.1.1 Targeting iron homeostasis Iron chelators such as deferoxamine, deferiprone, and deferasirox bind free ferrous iron (Fe2+), reducing substrate availability for the Fenton reaction and thereby curtailing the lipid peroxidation cascade (152)

People in the highest GGT quartile had nearly four times the risk of developing metabolic syndrome compared to those in the lowest quartile

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It results in a higher percentage of degraded RBCs, thereby reducing the RBC count and causing anemia during sepsis (eryptotic RBCs were degraded and cleared from circulation) [202, 230, 380]