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Split-face human dermatology trials on wrinkle depth and skin density (n usually under 50 per arm)

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Funding This work was supported by the University of Zagreb, Zagreb, Croatia (Grant BM 099)

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70 percent isopropyl alcohol prep pads, one per septum entry and one per injection site

other components cleared more rapidly The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all four components and their potential interactions