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Over years of study, it has demonstrated a strong safety profile, including: No negative impact on glucose metabolism No antibody formation in monitored trials No serious adverse events linked to its use A tolerability profile similar to placebo These findings support its long-term use within medically supervised weight loss programs

It modulates GABA receptors allosterically, influences dopamine and serotonin receptor activity, enhances enkephalin levels, and reduces neuroinflammation, all through a single compound

doi: 10.1212/01.wnl.0000247740.47667.03

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doi: 10.1210/jc.2011-2590 153 MekalaKCTritosNA