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8 In 1939, caloric restriction was subsequently reported to have extended the lifespan of rats and mice, 9 which was the first evidence that the aging process was regulated (Fig

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171 In a tumor environment, tumor immune escape mechanisms will clear eATP to avoid inflammasome and inflammation reaction, therefore, CD39 antibody which inhibits ATP transformation to AMP could enhance ATP-mediated activation of inflammasomes and the corresponding inflammatory response