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Fix: Treat it like a surgical procedure

B12 pooling can occur when there is not adequate transport

This is attributed to the direct activation of the protein sirtuin 3 (SIRT3) by HNK, which promotes ROS reduction and detoxification

It depends on both copper and zinc as cofactors, but only copper regulates its activity ( 2 O 2 , CuZn-SODs activity is suppressed, via oxidation of His-118 to form 2-oxo-histidine (Uchida and Kawakishi, 1994)

While it is produced in small amounts by the liver, it can also be introduced into the body through supplements and injections

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